| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3a1fbf1dce23cb388b673d1ab23a3fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1815 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-28 |
| filingDate |
2001-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0ea2876c7fb4660706ce7dcd8f9c5af |
| publicationDate |
2002-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6488910-B2 |
| titleOfInvention |
Methods for dissolving hyperpolarized 129 Xe gas using microbubbles |
| abstract |
Methods for increasing the T1 of injectable microbubble formulations of hyperpolarized 3He include the step of introducing the hyperpolarized 3He to a quantity of microbubbles held in a chamber and increasing the pressure therein to facilitate the movement or loading of the 3He into the microbubbles. Subsequently, a limited quantity of carrier liquid or a carrier liquid solution alone, or pre-mixed with 3He, can be introduced to the microbubble/3He in the chamber to inhibit the tendency of the 3He to leach out of the bubble. Related pharmaceutical products and associated containers as well as an evacuation based method for rapid mixing and delivery of the bubbles and the 3He is also disclosed. An additional method for dissolving 129Xe gas by using bubbles as an accelerant is also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009214433-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008284429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009252686-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008199401-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007082048-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6901281-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002168419-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2001041833-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7850152-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010092390-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8377419-B2 |
| priorityDate |
1998-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |