| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate |
1999-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4152c742f1d234e790fba05a06ec5867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fb58b98dae7be8837a91081789f69c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3130fb7bc9b2a2602218a3b1f059e59 |
| publicationDate |
2002-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6482864-B1 |
| titleOfInvention |
Sustained-release preparation of physiologically active polypeptide and production thereof |
| abstract |
A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous solution of the polypeptide which solution has a water-miscible organic solvent and/or a volatile salt; which improves the ease of handling of the physiologically active polypeptide powder in the process for producing the preparation; which makes it possible to industrially produce the sustained-release preparation in large scale; which provides a sustained-release preparation showing high and stable concentration of the active component in blood in long term, low initial release ratio of the physiologically active polypeptide, and high entrapment ratio of the polypeptide into the sustained-release preparation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021339-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009298780-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005159356-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005288479-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8637077-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236759-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7202326-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004057996-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7582312-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7521527-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006205663-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6723347-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007004616-A1 |
| priorityDate |
1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |