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publicationDate 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6465187-B1
titleOfInvention Method of treatment
abstract A method of treatment of mast cell mediated inflammatory disorders in mammals comprising regulating the longevity and activity of activated mast cells by inhibiting the expression and/or function of the anti-apoptotic A-1/bfl-1 gene or gene product. The invention also provides the development and use of a compound capable of inhibiting the expression and/or function of the anti-apoptotic A-1/bfl-1 gene or gene product for the manufacture of a medicament for treating mast cell mediated inflammation in human tissues by regulating the longevity and activity of activated mast cells.
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