| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9259cfa966fe620251340a003f5d6125 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-04 |
| filingDate |
2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ac3d0fb044c3b4b1dc2cc54296218e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4666c95babb5b1c0bd44920e438f394
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce352a8d9a3ee25c2540205214dbef7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c989a1cbb4dc51ac40c79e3777cb568c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da1feb2725d0b96bd21fafbcc4be780b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e7fe5b1144375f5fc1b9833dc31fb75 |
| publicationDate |
2002-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6452000-B2 |
| titleOfInvention |
Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate |
| abstract |
The present invention concerns an improved process for the preparation of asymmetric cyclic ureas as well as intermediates in the preparation of asymmetric cyclic ureas. In the process, a diamine of formula (I-a)is selectively monoacylated to give an asymmetric monoacylated diamine which can be converted into asymmetric intermediates. The asymmetric intermediates can be further alkylated, cyclized, and/or modified to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection. The invention allows for scalable preparation of a wide variety of asymmetrical cyclic ureas. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101130984-B1 |
| priorityDate |
1997-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |