| abstract |
Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts and solvates)whereinwherein one of Y and Z is -N- and the other is -N- or -CH-;X is -O-, -S-, -SO-, -SO2- or -CH2-;Q isR is alkyl, cycloalkyl, optionally substituted aryl or heteroaryl;R1, R2 and R3 are H or alkyl;R4 is alkyl, cyclolalkyl orR5 is H, alkyl, -C(O)alkyl, arylcarbonyl, -SO2alkyl, aryl-sulfonyl -C(O)Oalkyl, aryloxycarbonyl, -C(O)NH-alkyl or aryl-aminocarbonyl, wherein the aryl portion is optionally substituted;R6 is H or alkyl; andR7 is H, alkyl, hydroxyalkyl or alkoxyalkyl; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of treatment are also disclosed. |