http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6448031-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c31d756b30e9f6fe84a8d02899191b6c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0825 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 |
| filingDate | 1997-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_283d9b82287f21a330ccd9f6ed061266 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_788c2db2597ee66144abdd522e505268 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80f938ea02be9cbda4ea3f31cdacf003 |
| publicationDate | 2002-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6448031-B1 |
| titleOfInvention | Process for producing LH-RH derivatives |
| abstract | This invention relates to a method for producing an LH-RH derivative, characterized in that a peptide fragment shown by general formula (1): pGlu-His-Trp-OR1 (where R1 denotes a lower alkyl) and a peptide fragment shown by general formula (2): H-Ser-Tyr-X-Leu-Arg-Pro-Y (where X denotes an amino acid selected from the group consisting of D-amino acids such as D-Leu, D-Ser(But), D-Trp, and (2-napthyl)-D-Ala, and Gly, and Y denotes Gly-NH2, Azgly(Azaglycine)-NH2 or NHR2 (R2 is lower alkyl)) are allowed to react in the presence of chymotrypsin or a chymotrypsin-like enzymes, to produce the LH-RH derivative shown by general formula (3): pGlu-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y (where X and Y are as defined above). Since the method does not accompany a side reaction such as racemization, it enables simple separation and purification of LH-RH derivatives. Moreover the method enables to provide high yields, as well as recovery and recycling of unreacted peptide fragments, therefore it is valuable in industrial use. |
| priorityDate | 1996-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 178.