http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6444872-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2000-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53530f2e2512785cb880e2dccaba2ad2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72464cc8c97928441eb59f4bf9582cb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14ea9436d48fcec1b26aaec72334e6a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8c54bb16f2bd34d8ef9e30873a1c2d8 |
| publicationDate | 2002-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6444872-B1 |
| titleOfInvention | Large animal model of invasive pulmonary aspergillosis in an immunocompromised host |
| abstract | A model of systemic mold/Aspergillus infection in a profoundly immunocompromised host has been established in the beagle dog. The beagle was rendered immunosuppressed using a combination of total body irradiation and daily steroids, which provided a window of time where the mold could be successfully inoculated through a bronchoscope. This created a localized infection in one lung lobe, which subsequently spread diffusely throughout the lung parenchyma, and uniformly resulted in the animal's death. The invention contemplates the further study of the pathophysiology of opportunistic mold infections in vivo and also provides examples for the development of new antifungal agents and more effective combinations of agents. Finally, the invention contemplates the development of technology for the early detection of systemic mold infections. The inventors envision, that the use of the model should help save patients from clinical trials of antifungal drugs that may be effective in vitro without living up to the expectations in a clinical setting. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007113298-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005022258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11291680-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10022218-B2 |
| priorityDate | 1999-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 396.