| abstract |
Methods for identifying compounds which modulate the activity of human neuronal nicotinic acetylcholine receptors are provided. Invention methods employ DNAs encoding alpha and beta subunits of human neuronal nicotinic acetylcholine receptors, and the polypeptides encoded thereby. Test cells useful for conducting invention assays include mammalian and amphibian cells containing said DNA. Various combinations of subunits (i.e., one or more alpha2, alpha3, alpha4, alpha5, alpha6 and alpha7 subunits in combination with beta2, beta3 and/or beta4 subunits) can be employed for the invention assays. |