http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6437125-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc9d7e9a44d51faf66b84a23a5a34ba0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 |
| filingDate | 1999-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85376970865e48fab8ba10eef0246d04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eb4557558643063db3473f9f276b762 |
| publicationDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6437125-B1 |
| titleOfInvention | Process for the production of purine derivatives |
| abstract | The invention provides a method of rearranging a compound of formula (I), wherein R and R' are selected independently from hydrogen and C1-12alkyl; and R1 and R2 are selected independently from hydrogen, hydroxy, halo, C1-12alkyl- or aryl carbonate, amino, mono- or di-C1-12alkylamino, C1-12alkyl or arylamido, C1-12alkyl- or arylcarbonyl, C1-12alkyl- or arylcarboxy, C1-12alkyl- or arylcarbamoyl, C1-12alkyl, C2-12alkenyl, C2-12alkynyl, aryl, heteroaryl, C1-12alkoxy, aryloxy, azido, C1-12alkyl- or arylthio, C1-12alkyl- or arylsulfonyl, C1-12alkyl- or arylsilyl, C1-12alkyl- or arylphosphoryl, and phosphato; to form a compound of formula (II), wherein R, R', R1 and R2 are as defined for formula (I); said method comprising treating the compound of formula (I) with a palladium (0) catalyst and a (diphenylphosphino)nC1-6 alkane, wherein n is an integer of 1-6. The invention also provides methods of R making penciclovir and famciclovir using this rearrangement reaction. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473780-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009076270-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004097528-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006004027-A1 |
| priorityDate | 1998-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 227.