| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2a9d061bb94edb53550e546189b8d4a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J7-0418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-8206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J7-0445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J7-0427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2016-0021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2016-0036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0066 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M16-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-0065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M11-001 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M16-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M16-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12 |
| filingDate |
2001-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad3a0337a8fb04a341e4f3902a442436
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9f9b21ebd7f5405b6c1e4653202af3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9ff96d4c13e29adf63742d542ecf851 |
| publicationDate |
2002-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6427681-B1 |
| titleOfInvention |
Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
| abstract |
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient's breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02094200-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6890518-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7683029-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02094200-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10905836-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10905837-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003118510-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009036353-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004020405-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005152848-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004223917-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6838076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-007408-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006226405-A1 |
| priorityDate |
1993-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |