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filingDate 1999-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2002-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6423528-B1
titleOfInvention Herpes simplex virus-1 deletion variants and vaccines thereof
abstract Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of RL are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a ts mutation into the UL26 gene.
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