| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L101-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-0082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-0088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L101-00 |
| filingDate |
1999-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98d1b6d9d5f5d02b569753938de5e721
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76d310ebd4a850f3fc907fa4cc3944bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b80469575ceae875d35dcd3cb444b798 |
| publicationDate |
2002-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6419916-B1 |
| titleOfInvention |
Assay for compounds which affect conformationally altered proteins |
| abstract |
An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tissue homogenate (at pH 5.0 or less) with test compound to determine if altered protein in the homogenate is 10 cleared. The homogenate may be brain homogenate from a transgenic mouse infected with human prions. Compounds which are found to clear the altered protein are useful in preventing, arresting and/or reversing (i.e. treating) a disease associated with the conformationally altered protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8460885-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7153905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8658374-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006030505-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7470655-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011151798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010184054-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7659076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006258804-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392342-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005079149-A1 |
| priorityDate |
1999-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |