| abstract |
Peptide substrates, or acid addition salts thereof, wherein said peptide substrate is represented by formula (I):wherein R is a hydrogen, an amino-protective group, or a residue carrying one or two D- or L-amino acids; X is Lys or Arg; W is Phe or Phe(NO2), wherein Phe(NO2) is p-nitrophenylalanine; Y is Phe, Phe(NO2), Tyr, 3,5-diiodotyrosine, norleucine, Leu, Asp(Osbzl) or Met, wherein Obzl is benzyloxy; and Z is an aniline, an aminocoumarin or an aminonapthalene derivative, are disclosed. These compounds are specific substrates for human pepsin I and are useful in assaying the presence of human pepsin I or human pepsinogen I, and useful in diagnosing gastric diseases, such as gastric cancer and gastric ulcer. |