| abstract |
Apparatus and methods especially useful for detection of cancer using cellular, Tryptophan-associated autofluorescence are described. The apparatus includes a light source to produce a beam of light transmitted to a tissue via a two-way fiber optic bundle which, in one embodiment, is passed through a conventional endoscope. The light beam excites the tissue, resulting in an emission of primarily cellular autofluorescence at a wavelength of about 330 nm. Light from the tissue is directed back through the fiber optic bundle and passes through a photodetector. The photodetector produces a signal, representative of the intensity of the Tryptophan-associated autofluorescence. |