| abstract |
Disclosed are novel polymers derivatized with at least one -SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized-S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula:R is an organic radical. Each X' is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X' is the same and is a C2-C6 alkylene group, more preferably-CH2-, -CH2CH2-, -CH2CH2CH2- or -CH2CH2CH2CH2-. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites. |