| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78941ed5a01bfbcd48376e1fdb485b19 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate |
1999-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0baaecc486e50ffe28177de04ee5a774
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70dfb9a98f6a35bd170c61744ba88692
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a66b72198fe6dd763b5494220b7cad68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6a9691cff8173e5cc45de100bb228e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc73c70fcf1b1c3fcd572aca548bd9f2 |
| publicationDate |
2002-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6395479-B1 |
| titleOfInvention |
Androgen-metabolic gene mutations and prostate cancer risk |
| abstract |
This present invention identifies mutations in several androgen-metabolic genes (SRD5A2, CYP17, HSD3B2, and HSD17B3) and methods of using such mutations in the diagnosis and treatment of inheritable prostate cancer susceptibility. Isolation of genomic DNA of various racial/ethnic populations followed by SSCP scanning and direct PCR sequencing of the aberrant SSCP (single-strand conformation dependent DNA polymorphism) patterns allows for identification of the disclosed polymorphisms. Screening for the disclosed mutations establishes a differential distribution among various racial/ethnic groups as well as altered in vivo enzyme activity that parallels prostate cancer risk. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009226915-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005208658-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8008012-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008050836-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9952221-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11105808-B2 |
| priorityDate |
1998-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |