| abstract |
A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR 2 ″ comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CONR 2 ″ with elemental fluorine. The groups R, R′ and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R′ may also be nitro or chlorine. |