| abstract |
Compounds of the formulawherein:X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II:wherein:R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl;C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano;Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders. |