abstract |
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, wherein b is N Y1 or O; c is CY2 or N; d is CY2; e is CY1 or N; f is CY1 or N; g is CY1 or N; Y1 is hydrogen, C1-4 alkyl, or halogen; Y2 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy;A is and W, X, Z, R3, R4 and R5 are defined in the specification. |