| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d595ec481a2a081fed4aa2fd4ff52d8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-135 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56983 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 |
| filingDate |
2000-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a4721a65f28f72c26d9050fc33cf3bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237399e2dc986a184936362853a5a4dc |
| publicationDate |
2002-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6376171-B1 |
| titleOfInvention |
Methods of screening for antiviral compounds |
| abstract |
The present invention demonstrates that the M2-1 protein of respiratory syncytial virus has a conserved Cys3-His1 motif known to bind zinc ions in other proteins and that mutations of the predicted zinc coordinating residues in the Cys3-His1 motif affect the transcriptional antitermination activity of M2-1, its ability to interact with nucleocapsid protein, and the phosphorylation state of M2-1. This invention clearly demonstrates the requirement for conservation of the Cys3-His1 motif in order to maintain the functional integrity of the M2-1 protein. Therefore, the present invention provides for methods of designing and screening compounds for antiviral activity towards respiratory syncytial virus based upon the loss of function of the M2-1 protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002119446-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7205013-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007202492-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005084947-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008279892-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6830748-B1 |
| priorityDate |
1999-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |