| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8381805eba6d034fc77bd230dd02e6e2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S585-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F11-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate |
1998-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57658bae1fb15ec19915425be1bbaf56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_938511719513df3557f4d7c81ed83599 |
| publicationDate |
2002-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6346652-B1 |
| titleOfInvention |
Asymmetric ring-closing metathesis reactions involving achiral and meso substrates |
| abstract |
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M=C reaction site, contains a bidentate dialkoxide of at least 80% optical purity. Because the M=C reaction site is of a sufficient shape specificity, conferred in part by the dialkoxide of sufficient rigidity and a M=N-R1 site, reacting the composition with a mixture of two enantiomeric dienes results in an olefin metathesis product that has at least a 50% enantiomeric excess of one enantiomer in the mixture. A method is also provided for reacting a composition with a racemic diene mixture to generate a metathesis product that has an enantiomeric excess of at least 50%. Methods are also provided for catalytic enantioselective desymmetrization. One method involves an olefin metathesis reaction with a molecular substrate having a plane of symmetry to form a product free of a plane of symmetry. Another method provides a desymmetrization reaction to occur in the absence of solvent. A method for producing quaternary carbon centers through a desymmetrization reaction is also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10569261-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11214818-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11109596-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8598400-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8362311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10308962-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8829219-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4234522-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9446394-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9073801-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3868890-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008119678-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7094898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011077421-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007216458-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713808-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11104921-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017087710-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017087846-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7932397-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7250523-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9687834-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9079173-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011015430-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10173208-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005131233-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011237815-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018213554-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8350073-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9242240-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003113740-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8222469-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8546500-B2 |
| priorityDate |
1998-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |