| abstract |
Anylpiperazines of formula (1) useful as serotonin reuptake inhibitors and 5-HT1Dalpha receptor antagonists are disclosed herein:whereinR1 and R2 are each independently hydrogen, halo, -(C1-C6)alkyl or -(C1-C6)alkoxy;R3 is hydrogen or -(C1-C6)alkyl;Y is -CO- or -CH2-;Z is -NH-, -N(COR)- or -CH2- where R is -(C1-C6)alkyl or -(C3-C8)cycloalkyl;<CUSTOM-CHARACTER FILE="US06342498-20020129-P00900.TIF" ID="CUSTOM-CHARACTER-00001"> represents a double or single bond;n and m are an each independently integer from 1 to 3, both inclusive; or a pharmaceutically acceptable salt thereof. |