Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5e95156255d5fe8b2923c544786e176 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
filingDate |
1999-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2001-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cc56c50913d7bf019a861e6a4c66f11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08957ee6059d78ef7c7abcd6357316f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209397ee7b19b74d5de8aa3dfcac0db5 |
publicationDate |
2001-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6331526-B1 |
titleOfInvention |
Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides |
abstract |
A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons -29 to -24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009280112-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267027-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9381246-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10357509-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008219997-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11077133-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935784-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772904-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7939080-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10543226-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7625859-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021193143-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9834575-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016164916-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579364-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10206942-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265339-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008206231-A1 |
priorityDate |
1993-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |