| abstract |
The present invention relates to novel optionally substituted 8-cyano-1-cyclo-propyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives, of the general formula (I) n in which n R 1 represents hydrogen, C 1 -C 4 -alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, n R 2 represents hydrogen, benzyl, C 1 -C 3 -alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, radicals having the structures —CH═CH—COOR 3 , —CH 2 CH 2 COOR 3 , —CH 2 CH 2 CN, —CH 2 CH 2 COCH 3 or —CH 2 COCH 3 , in which R 3 represents methyl or ethyl, or a radical of the general structure R 4 —(NH—CHR 5 —CO) n —, in which R 4 represents hydrogen, C 1 -C 3 -alkyl or the radical —COO-tert-butyl, R 5 represents hydrogen, C 1 -C 4 -alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n is 1 or 2, and n Y is oxygen or sulfur, n the process for their preparation and their use in antibacterial compositions. |