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publicationDate 2001-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6316004-B1
titleOfInvention Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals
abstract Chimeric polypeptides having the immunogenicity of somatostatin include an amino acid sequence of somatostatin-14 and a protein carrier. The sequence of somatostatin-14 is joined to the 3'-end of the protein carrier by a spacer (Sp)n, wherein Sp consists of an alkaline amino acid and an amino acid that provides a rigid expended chain-like beta-structure, and n designates the number of blocks in the spacer. In a preferred embodiment, n is from 1 to 8 and the protein-carrier is chloramphenicol acetyl transferase (CAT).
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