| abstract |
New compounds of formula Iwherein:R and R1 are independently selected from hydrogen, (C1-C6)alkyl, styryl and (C3-C6)cycloalkyl or, taken together with the carbon to which they are linked, form a (C3-C6)cycloalkyl group;A is selected from the following groups:-CH2C=CCH2-,or -(CH2)q-NH-(CH2)q-,wherein q is an integer from 2 to 3B is selected fromT is selected from -CH2-C=CH, -C=CH, -(CH2)p-R3, -CH=CH-R3, -CH2-NHCO-R3, -(CH2)p-O-R3, -CH(NH2)-CH2R3, in which p is 0 or an integer from 1 to 4,R3 is a carbocyclic or heterocyclic ring as medicaments having antitumor and/or antimetastatic activities. |