| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_826dad2d8b0c581e3011b33df7f4a8b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc41c62f166edca871319a8b7dd300ef |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16222 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-14 |
| filingDate |
1999-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0093b5e6a99ae291e79cc1d792a310e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddb6f5537127e52cfde9f6f2572b991f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c472187884bc2b8ec14c1b01cb329e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c8cd47d1960dcd90378bb30f91ae7d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d2c5636c5220591822eb8684c64a8ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4479a2e79137120391b628cd5c6091f3 |
| publicationDate |
2001-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6303764-B1 |
| titleOfInvention |
Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids |
| abstract |
The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007197807-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10317404-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014165536-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473798-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018050429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11209433-B2 |
| priorityDate |
1998-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |