| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_620ecb9324409347c27e96b6071503ee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-192 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
1998-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16b3b68bfea85dd9129803e91058c66e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6ed028cec8aac50293f00aeb36998d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b25f7cd3f70a474a8ba468ebef2fdea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1575bbee72fd2acf1f9523ee5181f93d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df74e8d40aa34d93302bd93d7c987eb4 |
| publicationDate |
2001-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6300364-B1 |
| titleOfInvention |
Medicinal compositions with cholesterol-lowering effect |
| abstract |
Pharmaceutical compositions having a cholesterol-lowering effect which comprises as the active ingredient a compound having a PPAR (peroxisome proliferator-activated receptor)delta activating effect or a PPARdelta- and PPARgamma-activating effect or a pharmaceutically acceptable salt thereof; pharmaceutical compositions wherein the cholesterol-lowering effect is an LDL-cholesterol-lowering effect; and a method for identifying a compound having a cholesterol-lowering effect characterized by measuring the PPARdelta-activating effect or the PPARdelta- and PPARgamma-activating effect thereof. Means for Solution: It is found out that a compound exerting an excellent cholesterol-lowering effect on higher animals such as humans and ape has an effect of activating PPARdelta or PPARdelta and PPARgamma. Also, a method for identifying a compound having an excellent cholesterol-lowering effect was found, wherein the desired compound can be quickly and efficiently screened from among a number of compounds by measuring the PPARdelta-activating effect or the PPARdelta- and PPARgamma-activating effect. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008009631-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008009525-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008030604-A2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005054674-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004077689-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005239854-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009298896-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006034184-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7396642-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7648999-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7652045-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008030595-A2 |
| priorityDate |
1997-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |