| abstract |
This invention provides a taxane derivative of the formula: n wherein a hydrophobic organic moiety is attached to a taxane. R and R 1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R 1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers. |