| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9089461ee71353d9df911820ff129558 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
1998-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8509b93457a0372a3043f1b93f4d77a |
| publicationDate |
2001-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6290951-B1 |
| titleOfInvention |
Alteration of the cell cycle in vivo, and particularly for inducing apoptosis of tumor cells |
| abstract |
A first substance (such as the peptide aldehydes LLnL and LVP) inhibits the function of intracellular proteasome. A second substance (such as ranpirnase) inhibits intracellular protein synthesis or increases intracellular expression of a cyclin-dependent kinase (CDK) inhibitor. Both substances are administered in such a manner that the effects thereof are coincident. The cell cycle of affected tumor cells is therefore arrested and the cells die of apoptosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846030-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702672-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005037497-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006093585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008249050-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11684679-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7749491-B2 |
| priorityDate |
1998-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |