| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3eb62223726704e46c983cf794773f7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07ba5e7ff356b7eda43fdfc20eef4b0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D255-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D259-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C305-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D259-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D255-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D203-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 |
| filingDate |
2000-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb07a3eac2ac61a38a6b41c73f999b15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb432a102b494181ffd6d10e83a7da6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fb689af5e60778e6666cc1950e61130
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f6368a88afffb2dec8d70f5b6c98654
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e3677be565781d62979d31225282813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c40aa2a9f056abaa95cbb1ae8e0ddbfa |
| publicationDate |
2001-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6288224-B1 |
| titleOfInvention |
Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylethyl-ethanolamine sulphonate esters as intermediates |
| abstract |
Aziridines may be subjeted to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I)where each R1 is independently hydrogen or a group AR and Ar is an optionally substituted phenyl group. The process comprises reacting a purified N-arylmethylethanolamine-sulphonate sulphonate ester with a base. N-aryimethyl-ethanolamine sulphonate ester of the formula R'NHCH2CH2OSO3H, wherein the N-arylmethyl group R' is an N-(bisarylmethyl) or N-(triarylmethyl) group, as intermediates. In a further aspect, the invention provides compounds of formula (II)where Ar and R1 are as hereinabove defined and at least two differing ArCHR21 moieties are present. |
| priorityDate |
1995-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |