| abstract |
Intermediates useful for the synthesis of huperzine A represented by the structures below,and methods for their synthesis, wherein:R1 is lower alkyl, benzyl, or substituted benzyl;X is a suitable leaving group;Y is an electron withdrawing group that can subsequently be converted into an amino group;one broken line is present as a carbon-carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon-carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2. |