| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8090a5ea39f9b1b1658845081b6952ab |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6858
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
1995-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6634734f566cce0ac896f1e6d67b416f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f23a8cbcebd27e44029d8a186bde4e06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2b39d1f5f2df18574812d2154454a70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c91eec33300dae222e21e0dac3ee2f96 |
| publicationDate |
2001-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6270963-B1 |
| titleOfInvention |
Method for testing for mutations in DNA from a patient sample |
| abstract |
A hierarchy of at least two assay techniques is utilized in testing for disease-associated mutations. The first assay in the hierarchy is selected to provide a highly specific test for the existence of the disease-associated mutation, although the accuracy of the test need not be high. The final assay in the hierarchy is selected to provide a highly accurate and highly specific test for the existence of the disease associated mutation. Intermediate tests of progressively greater accuracy may also be included in the hierarchy. Once the hierarchy has been selected for a given mutation-associated disease, a patient sample is analyzed the patient sample using the first, lowest accuracy assay in the hierarchy. If the result of the first assay is negative for the presence of a disease-associated mutation, then the next assay in the hierarchy is performed. This process is repeated until the final assay has been performed on all samples which gave negative results when tested by all less-accurate assays in the hierarchy. The test may be used for diagnosis and targeted screening for p53 mutations and mutations in the RB1 gene. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7801683-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7209835-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7803548-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8076078-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9840740-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8460871-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793910-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7402399-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015127378-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9228237-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005131006-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004091916-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010317017-A1 |
| priorityDate |
1994-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |