| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e14d6eb6e2b529693a4fd5c5238b4e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-6555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R31-3185 |
| filingDate |
1998-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4e44ec09f0220a2ab54c8b87330445d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f778ae8da13d42960885e18e70a9f535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f62e7e5c64df491e49089db8aec4c0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8159138c8b2570f715a8b90b6eb56cdb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b449a8cf216ceff030b8b4b7c5c7d7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c92972dc09c093cc490cc36138fe78e |
| publicationDate |
2001-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6265375-B1 |
| titleOfInvention |
Conformationally constrained backbone cyclized peptide analogs |
| abstract |
Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are Nalpha(omega-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these Nalpha(omega-functionalized) amino acids are incorporated into a peptide sequence, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is specifically exemplified by backbone cyclized bradykinin antagonists having biological activity. Further embodiments of the invention are somatostatin analogs having one or two ring structures involving backbone cyclization. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261215-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6914122-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7189856-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002016294-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005266496-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005090429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011024175-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008242600-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003191134-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015087334-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03059933-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005226813-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017212477-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8198218-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010022499-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020170249-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03059933-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7700717-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022003673-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006211507-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019058365-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013111129-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10662225-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005267017-A1 |
| priorityDate |
1994-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |