| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16a85abf6a48de2e34e9b2ac4f7305c0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
1999-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_944bed292fc258e9a5627938c7d64f23 |
| publicationDate |
2001-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6245966-B1 |
| titleOfInvention |
Adenoviral mediated gene transfer into lymphocytes |
| abstract |
The present application shows that the expression of Coxsackievirus and/or Adenovirus (CAR) in various lymphocyte cell lines is sufficient to facilitate the efficient transduction of these cells by adenoviruses. This property of CAR does not require its cytoplasmic domain. Use of a truncated CAR (tCAR) lacking the cytoplasmic domain has the unexpected advantage in that integrin expression is not increased in lymphocytes expressing tCAR, whereas lymphocytes expressing full-length CAR exhibit upregulated integrin expression. Further provided are transgenic mice which have been genetically engineered for tissue-specific (lymphocyte) expression of tCAR. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005106679-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03054012-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104490937-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003185815-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2002353224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011076304-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03054012-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100469888-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104490937-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003093147-A1 |
| priorityDate |
1998-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |