| abstract |
Novel compounds of the formula:or a pharmaceutically acceptable salt or solvate thereof, wherein:a represents N or NO-;R1 and R3 are the same or different and each represents halo;R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H;T is a substituent selected from SO2R or:Z is O or S;n is zero or an integer from 1 to 6;R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2;R5 is H, alkyl, aryl, heteroaryl or cycloalkyl.Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells. |