| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2658d45a8e9c71b9598e2bf83242bab3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
1999-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45fe56506c898d417f7ed870cdc6de9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f0fe32d2a782dab6c58043028e2bcc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8e29165da9a33c52bba72ab974bd630
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78a3d3a02e7b7cbc7e1b56ad362bd18d |
| publicationDate |
2001-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6235873-B1 |
| titleOfInvention |
Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes |
| abstract |
The invention is directed to constitutively active Stat proteins and methods for their preparation. The modified Stat proteins have at least one cysteine residue which may interact with the corresponding cysteine residue on another modified Stat protein to form a dimer. The constitutively active Stat proteins are capable of binding to DNA and activating transcription in the absence of tyrosine phosphorylation. Cell lines expressing the modified Stat protein exhibit a transformed phenotype and are capable of forming tumors in nude mice. Methods are describe utilizing the modified Stat proteins of the invention in the absence and presence of tyrosine phosphorylation in identifying agents capable of modulating Stat protein dimerization, transcriptional activity, and cellular transformation in vitro and in vivo. The invention is also directed to polynucleotides encoding modified, constitutively active Stat proteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004175369-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005107590-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7365160-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007060521-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003157711-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005112551-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007072822-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009227489-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03070915-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03068952-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03070915-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003153014-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7510870-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6379894-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0220032-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7638122-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9345682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004209246-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010297061-A1 |
| priorityDate |
1999-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |