| abstract |
The invention discloses use of a compound of the benzofuroxan series for treatment of cardiovascular disorders represented by the general formula (I)and pharmaceutically acceptable salts thereof wherein:R is halogen, acetoxy, -X-R', -C(O)NR''R''', or -C(O)Cl;X is oxygen, sulfur, -C(O)-, or -C(O)O-;R' is hydrogen, straight chain or branched lower alkyl (C1-C8);R'' and R''' are independently hydrogen, straight chain or branched lower alkyl (C1-C8) or R'' and R''' are linked together with or without a heteroatom selected from the group consisting of oxygen and nitrogen wherein substitution on nitrogen is with hydrogen or lower alkyl.The invention further discloses pharmaceutical compositions containing compounds of general formula I as active ingredients.The invention also discloses a method of treatment of mammal, including man, of coronary heart disease by administration of an effective amount of a compound of formula I as defined above. |