| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc408585f6863d7865c90ab9a4632135 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-064 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate |
1998-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a105cc3f07d606711dd7147fcc9dbefe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4714b333ac06e80ecfd2f13039ee674
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_028a05079cd20df3cabbea2081255521 |
| publicationDate |
2001-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6224859-B1 |
| titleOfInvention |
Composition containing immature mammalian dendritic cells for enhancing tolerogenicity to foreign graft |
| abstract |
A novel transplantation method for enhancing tolerogenicity in a host mammal to a transplant graft specimen from a donor mammal is disclosed. According to this method, immature mammalian dendritic cells propagated in the presence of a cytokine are administered to the host mammal in advance of transplantation. Tolerogenicity is enhanced in the host mammal when the immature mammalian dendritic cells concentrate in T-dependent regions of secondary lymphoid tissue of the host mammal, where the expression of major histocompatibility complex class II antigen by the immature mammalian dendritic cells is upregulated. Also disclosed is a novel method of effecting the maturation of immature dendritic cells in the presence of a cytokine and an extracellular matrix protein. These mature mammalian dendritic cells, which upregulate the expression of major histocompatibility complex class II antigen, can then be used to enhance the immune response of a host mammal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006147432-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004072348-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03083089-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006292618-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7465448-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2305277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004161425-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7763251-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003022252-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03083089-A2 |
| priorityDate |
1995-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |