http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6218138-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0ed027c7371bb9c0dab444bffd2b211 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-04 |
| filingDate | 1999-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7035b4e11b1abe3e48fc00da7e0ff45e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fe9ffc526515f67aa423018c62c976d |
| publicationDate | 2001-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6218138-B1 |
| titleOfInvention | Synthesis of beta-lactam antibiotics with immobilized penicillin amidase |
| abstract | Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase from E. coli covalently immobilized on support particles. The resulting beta-lactam antibiotic product is solubilized by adding an acid such as sulfuric acid to lower the pH to 1.0 at a temperature in the range of 0° C. to +5° C. The immobilized penicillin amidase is substantially inactivated by the acid. After separating the beta-lactam antibiotic product, the immobilized penicillin amidase is substantially reactivated for reuse in antibiotic synthesis by treatment with a buffer having about a neutral pH. Antibiotics that can be produced include ampicillin, amoxicillin, cephalexin, cefaclor and cefadroxil. Support particles that can be used include particles having a macroporous structure and a particle diameter of 10-1000 mum, particles having oxirane groups, particles made of a synthetic polymer and inorganic particles such as porous glass particles. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004062558-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019010447-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004062558-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8173403-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010047883-A1 |
| priorityDate | 1998-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.