http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6211395-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 |
| filingDate | 2000-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f9481dfe28fb1495e063f858206d066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f127b20da80f3afc38ccf7ee7fa5aaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a011385edb968a543218f5a4d3350d56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38995cb88cc9d802e675de407e77e156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03865b5de178371079a435ba5f798576 |
| publicationDate | 2001-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6211395-B1 |
| titleOfInvention | Enantioselective synthesis of 3-aminopyrrolidines |
| abstract | The invention relates to a process of preparing a chiral compound of the formula:wherein R1 is selected from the group consisting of hydrogen and lower alkyl, and R2 and R2' are the same, and R2 and R2' are selected from a group consisting of hydrogen and primary alkyl, or R2 and R2' taken together form a C3 to C6 cycloalkyl, comprising the steps of chirally reducing a beta-keto ester to afford a beta-hydroxy ester, activating the beta-hydroxy ester by treatment with a sulfonic acid or a derivative thereof to provide an activated compound having sulfonate leaving group, displacing the sulfonate leaving group with an azido moiety, or treating the activated compound with an alkylamine, deprotecting and cyclizing to afford a pyrrolidinone, and reducing the pyrrolidinone to afford a stereoisomerically preferred 3-aminopyrrolidine derivative. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8729063-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8362003-B2 |
| priorityDate | 1998-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 264.