| abstract |
The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I):(whereinR1 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; X1-X2-X3 represents CR5=CR6-CR7=CR8 (wherein R5, R6, R7 and R8, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, hydroxy, substituted or unsubstituted lower alkoxy, etc.), N(O)m=CR5-CR6=CR7 (wherein R5, R6 and R7 have the same significances as defined above, and m represents 0 or 1), S-CR7=CR8 (wherein R7 and R8 have the same significances as defined above), etc.;and when R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group,(wherein n is 0 or 1; R3 and R4, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl, etc., or R3 and R4 may be combined together to form cyclic alkyl; and Q represents hydroxy, halogen, etc.), etc., Y represents -CH2SO2-, -SCH2-, -SOCH2-, -SO2CH2-, etc.) and pharmaceutically acceptable salts thereof. |