http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6197966-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_832999f230974e686160c11f3929678d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b65747ed78f05dd9ebe107b50ce2855 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D321-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D321-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28 |
| filingDate | 1999-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f772a5714e1e69bc2bf27319158b06e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93117ffa28b4f00ce82a03f07a43da2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4f277f0490897ca61377c7ca6fd3911 |
| publicationDate | 2001-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6197966-B1 |
| titleOfInvention | Production method of optically active amino alcohols |
| abstract | A method for producing an optically active amino alcohol compound of the formula [3], an enantiomer thereof or a salt thereof, comprising reacting a mesoepoxide compound of the formula [1] with a compound of the formula [2] in the presence of a mixed catalyst comprising a Lewis acid and a proton donor:wherein R1, R2 and R3 are each H, an optionally substituted lower alky, and the like, or R1 and R1 or R2 and R3 may form an optionally substituted ring; and R4 and R5 are each H, an optionally substituted lower alkyl, and the like, or R4 and R5 may form an optionally substituted ring together with the adjacent N, or an imide group or azide group together with the adjacent N, and R6 is H or a silyl group. The present invention enables stereoselective production of a desired intermediate compound, which is an HIV protease inhibitor, extremely efficiently as compared to conventional methods. The method of the present invention is a very useful method which can be used not only for the production of said intermediate compound but also for the production of various other compounds. |
| priorityDate | 1998-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 281.