| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D477-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-00 |
| filingDate |
1999-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfc71943eb45e6f254fc286428033e6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1872be48a1690c57cf64d81dd56bbaf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23e7f717c00c80a607af2bd02866e78a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1afea00a97703397b81e746ea81a56fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382fb354c78389a7e84f8f23f6a65485 |
| publicationDate |
2001-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6194568-B1 |
| titleOfInvention |
Process for synthesizing carbapenem intermediates |
| abstract |
The invention describes an improved process for synthesizing 1-beta-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention.The invention relates to the synthesis of a compound of formula 3:wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein. |
| priorityDate |
1998-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |