| abstract |
This invention relates to a heterocyclic compound of the formulawhereina group of the formula:is a group of the formulaX is O, S or N-R5,R1 is lower alkyl, etc.,R5 is hydrogen, lower alkyl, etc.,R2 is hydrogen, halogen, lower alkyl, etc.,R3 is halogen, lower alkyl, etc.,R4 is amino optionally having suitable substituent(s),andA is lower alkylene,and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals. |