| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a22da5b7dd6ed60a21538e5edb23e051 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A40-146 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8216 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 |
| filingDate |
1997-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0077e35f4a51c1e89acb3478c592694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f032a1fb7c0ce4987577ec4363d7f95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36b95bdecd86a905c213ed154afe266e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7648fab4ea12337296319509853416da |
| publicationDate |
2001-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6180774-B1 |
| titleOfInvention |
Synthetic DNA sequences having enhanced expression in monocotyledonous plants and method for preparation thereof |
| abstract |
A method for modifying a foreign nucleotide sequence for enhanced accumulation of its protein product in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by reducing the frequency of the rare and semi-rare monocotyledonous codons in the foreign gene and replacing them with more preferred monocotyledonous codons is disclosed. In addition, a method for enhancing the accumulation of a polypeptide encoded by a nucleotide sequence in a monocotyledonous plant and/or increasing the frequency of obtaining transgenic monocotyledonous plants which accumulate useful amounts of a transgenic protein by analyzing the coding sequence in successive six nucleotide fragments and altering the sequence based on the frequency of appearance of the six-mers as to the frequency of appearance of the rarest 284, 484, and 664 six-mers in monocotyledonous plants is provided. Also disclosed are novel structural genes which encode insecticidal proteins of B. t. k. and monocotyledonous (e.g. maize) plants containing such novel structural genes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010096613-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101818157-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-015908-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003192078-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8344207-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009238798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102766652-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-2519-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008201806-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007027777-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034997-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102766652-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10006046-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003226171-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022204466-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022204464-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6720475-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9428765-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101268094-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8581047-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7741118-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009505679-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8080647-B2 |
| priorityDate |
1993-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |