| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96466
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 |
| filingDate |
1999-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638503917537de6f9d46d13515f42f36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69caa1c996f640954b019775da9ed11 |
| publicationDate |
2001-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6177259-B1 |
| titleOfInvention |
Assays and kits for inhibition of polyglutamine-induced cell death |
| abstract |
The invention provides a method of screening for an inhibitor of cell death, comprising an assay comprising the steps of incubating a first protein comprising a caspase, a second protein comprising a polyglutamine stretch and a candidate inhibitor of cell death under conditions sufficient to permit the formation of a complex comprising the first protein and the second protein, and performing a detection step to detect the formation of a complex, wherein a reduction in the formation of a complex in comparison to that observed when the first and second proteins are incubated in the absence of the candidate inhibitor indicates that the candidate inhibitor is an inhibitor of cell death. A further aspect of the invention is a kit with which to perform this method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005221272-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7015012-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004018529-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005095270-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02064618-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6648918-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02080855-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005271897-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02064618-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010260682-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7387614-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8512971-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02080855-A2 |
| priorityDate |
1998-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |