| abstract |
Pharmaceutical compounds of the formula: ##STR1## in which n is 1 to 6, m is 1 or 2 and p is 1 or 2, R 1 and R 2 are each hydrogen, C 1-4 alkyl, C 1-4 alkoxy, HO--C 1-4 alkyl, C 1-4 alkoxy-C 1-4 alkyl, C 1-4 alkylthio, halo, optionally substituted phenyl, optionally substituted phenyl-C 1-4 alkyl, or R 1 and R 2 together with the carbon atom to which they are attached form a C 3-6 cycloalkyl group, >C═O, C═NOR' where R' is hydrogen or C 1-4 alkyl, n R 3 , R 4 and R 5 are each hydrogen, halo, nitro, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkyl-CO--, where m is 0, 1 or 2, R'R"N--SO 2 --, --COOR', --CONR'R", --NR'R", --N(OR')COOR", --COR', --NHSO 2 R', where R' and R' are each hydrogen or C 1-4 alkyl, n R 6 and R 7 are each hydrogen or C 1-4 alkyl, n X is oxygen or sulphur, n the dotted line represents an optional double bond, and the fluorine atom is attached at the 6- or 7-position; and salts thereof. |