| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate |
2000-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f389f777f698ff7058766a1176a752a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a374284481e9c3dbafa98e59daea5ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2a4cc707b28311c2ad9a86d1b10d7ed |
| publicationDate |
2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6150410-A |
| titleOfInvention |
pH independent extended release pharmaceutical formulation |
| abstract |
Pharmaceutical formulations of acidic pharmacologic agents which demonstrate improved uniformity of release over the wide range of pH values encountered between the stomach and intestinal tract comprise an acidic pharmacologic agent dissolved or dispersed in a matrix comprising about 10 weight percent to about 40 weight percent of a a neutral water-swellable hydrophilic polymer and 20 weight percent to about 50 weight percent of an acid-soluble polymer which swells in water at pH values above about 5. A particularly preferred formulation comprises divalproex sodium. Also disclosed are pre-tablet granulations and process for preparing both the pre-tablet granulation and the tablet unit dosage form. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02065991-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003211148-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02065991-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02051402-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02051401-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004146556-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6511678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7445796-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02051401-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006257473-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004096182-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009099151-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6316460-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6528090-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6528091-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004016249-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006124421-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004156897-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004156898-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6419953-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6720004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6713086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006159752-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6548513-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002031549-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1216704-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004033266-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1219295-A1 |
| priorityDate |
1999-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |