http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6143875-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 1998-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ddb9cb1a5eca19afac9326e9c4d526d |
| publicationDate | 2000-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6143875-A |
| titleOfInvention | Antibody to DNase involved in apoptosis |
| abstract | The present invention relates to novel DNases alpha , beta and gamma capable of selectively cleaving the linker sites of chromatin DNA. The present invention also relates to novel DNase gamma involved in fragmentation of chromatin DNA in apoptosis. The present invention further relates to amino acid sequence of DNase gamma , DNA encoding said enzyme, nucleotide sequence of said DNA, recombinant vector containing said DNA, transformant containing said recombinant vector, production method of DNase gamma comprising culture of said transformant, and antibody having affinity for said DNase gamma , precursor thereof and the amino acid sequence of fragments thereof. The DNase gamma of the present invention takes part in the control system of apoptosis, and effectively contributes to the development of medications for the prevention, treatment and diagnosis of apoptosis-inhibitory or promotive diseases such as cancer, autoimmune diseases and viral infections. In addition, the DNases alpha and beta of the present invention increase upon viral infection to cleave viral DNA, and are useful for the development of therapeutic agents for viral infections. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005017483-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006036711-A |
| priorityDate | 1994-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 518.